Modified-release oral calcifediol corrects vitamin D insufficiency with minimal CYP24A1 upregulation
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چکیده
منابع مشابه
Modified-release oral calcifediol corrects vitamin D insufficiency with minimal CYP24A1 upregulation
Vitamin D insufficiency is prevalent in chronic kidney disease (CKD) and associated with secondary hyperparathyroidism (SHPT) and increased risk of bone and vascular disease. Unfortunately, supplementation of stage 3 or 4 CKD patients with currently recommended vitamin D2 or D3 regimens does not reliably restore serum total 25-hydroxyvitamin D to adequacy (≥30ng/mL) or effectively control SHPT....
متن کاملCalcitriol/calcifediol ratio: An indicator of vitamin D hydroxylation efficiency?
BACKGROUND Calcifediol (25D) availability is crucial for calcitriol (1,25D) synthesis, but regulation of vitamin D hydroxylases is majorly responsible for 1,25D synthesis. The net efficiency of vitamin D hydroxylases might be informative. We assume that the ratio between calcitriol and calcifediol (25D/1,25D) serum concentrations could suggest the vitamin D hydroxylation efficiency. METHODS W...
متن کاملVitamin D insufficiency.
Vitamin D deficiency, which classically manifests as bone disease (either rickets or osteomalacia), is characterized by impaired bone mineralization. More recently, the term vitamin D insufficiency has been used to describe low levels of serum 25-hydroxyvitamin D that may be associated with other disease outcomes. Reliance on a single cutoff value to define vitamin D deficiency or insufficiency...
متن کاملVitamin D-insufficiency
BACKGROUND Vitamin D insufficiency is increasingly recognized as an important risk factor in the pathogenesis of falls and fractures and may increase the risk of other diseases. The aim of this study was to obtain information about the vitamin D supply from a representative cohort of the German population. METHODS 264 General practitioners participated in the DeViD-Trial (D-Vitamin in Deut...
متن کاملVitamin D deficiency and insufficiency.
30–35 ng/ml [6]. Priemel et al. [7], in their autopsy study, found that about 40% of bone samples from individuals with serum 25-OHD of 20–32 ng/ml still had elevated osteoid volumes typical for vitamin D deficiency. However, no osteomalacia was found in samples taken from individuals with serum levels higher than 32 ng/ml. In a meta-analysis, Bischoff-Ferrari and colleagues [8] showed that a s...
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ژورنال
عنوان ژورنال: The Journal of Steroid Biochemistry and Molecular Biology
سال: 2015
ISSN: 0960-0760
DOI: 10.1016/j.jsbmb.2014.11.022